Pilot RCT of D-cycloserine-augmented ERP in adolescents with OCD

• Research type

  Research Study

• Full title

  A randomised double-blind placebo-controlled pilot study of D-cycloserine-augmented exposure therapy in adolescents with obsessive-compulsive disorder

• IRAS ID

  5458

• Contact name

  Isobel Heyman

• Sponsor organisation

  King's College London

• Eudract number

  2008-006947-38

• Research summary

  This study is a pilot study to look at the effect of administering d-cycloserine (a medicine) to enhance exposure-based cognitive behaviour therapy (CBT) in the treatment of adolescents with obsessive-compulsive disorder. The study will randomly allocate participants to one of two treatment conditions; either CBT plus-cycloserine or CBT plus a placebo pill. Treating clinicians and researchers will not know which participants will receive d-cycloserine and which will receive the placebo pill. Treatment effects will be carefully evaluated in order to determine whether d-cycloserine is successful in enhancing the success of cognitive behaviour therapy in adolescents.

• REC name

  London - Dulwich Research Ethics Committee

• REC reference

  08/H0808/203

• Date of REC Opinion

  26 Nov 2008

• REC opinion

  Favourable Opinion