PICSO ViPER

  • Research type

    Research Study

  • Full title

    Understanding the effects of Pressure-controlled Intermittent Coronary Sinus Occlusion assisted percutaneous coronary intervention on coronary physiology and left ventricular performance. The Pressure-controlled Intermittent Coronary Sinus Occlusion on VentrIcular PERformance study

  • IRAS ID

    263529

  • Contact name

    Giovanni Luigi De Maria

  • Contact email

    GiovanniLuigi.DeMaria@ouh.nhs.uk

  • Sponsor organisation

    Oxford University Hospitals - NHS Foundation Trust

  • Clinicaltrials.gov Identifier

    NCT04032925

  • Duration of Study in the UK

    2 years, 0 months, 1 days

  • Research summary

    Patients with impaired pump function of the heart, who experience heart attacks, are at greater risk of adverse outcomes than those with normal function. In these patients, a new technique (pressure-controlled intermittent coronary sinus occlusion [PISCO]) which improves the blood supply to the heart by increasing pressure in the heart veins, may improve heart pump function and thereby reduce overall risk.

    We propose a study of this new technique using state of the art invasive measurements, in patients who have experienced heart attacks and are having coronary angioplasty as part of their routine care. We aim to acquire measurement of heart pump function and coronary artery blood flow before and after coronary angioplasty supported with this device to accurately assess the effects of PISCO therapy. Further understanding of the mechanism of the potential clinical benefits of this new therapy is key to designing larger outcome clinical studies to evaluate its efficacy.

  • REC name

    South Central - Oxford C Research Ethics Committee

  • REC reference

    19/SC/0455

  • Date of REC Opinion

    13 Dec 2019

  • REC opinion

    Further Information Favourable Opinion