PICSO ViPER
Research type
Research Study
Full title
Understanding the effects of Pressure-controlled Intermittent Coronary Sinus Occlusion assisted percutaneous coronary intervention on coronary physiology and left ventricular performance. The Pressure-controlled Intermittent Coronary Sinus Occlusion on VentrIcular PERformance study
IRAS ID
263529
Contact name
Giovanni Luigi De Maria
Contact email
Sponsor organisation
Oxford University Hospitals - NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Patients with impaired pump function of the heart, who experience heart attacks, are at greater risk of adverse outcomes than those with normal function. In these patients, a new technique (pressure-controlled intermittent coronary sinus occlusion [PISCO]) which improves the blood supply to the heart by increasing pressure in the heart veins, may improve heart pump function and thereby reduce overall risk.
We propose a study of this new technique using state of the art invasive measurements, in patients who have experienced heart attacks and are having coronary angioplasty as part of their routine care. We aim to acquire measurement of heart pump function and coronary artery blood flow before and after coronary angioplasty supported with this device to accurately assess the effects of PISCO therapy. Further understanding of the mechanism of the potential clinical benefits of this new therapy is key to designing larger outcome clinical studies to evaluate its efficacy.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
19/SC/0455
Date of REC Opinion
13 Dec 2019
REC opinion
Further Information Favourable Opinion