PICSO in NSTEMI Randomised Controlled Trial
Research type
Research Study
Full title
PICSO in NSTEMI registry. Pressure controlled intermittent coronary sinus occlusion in Non-ST elevation Myocardial Infarction. An observational registry
IRAS ID
153084
Contact name
Piers Clifford
Contact email
Sponsor organisation
Buckinghamshire Healthcare NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
In STEMI patients, treated with early reperfusion, microvascular obstruction, also known as no reflow, has been reported in more than 30% of patients. MVO is associated with advanced myocardial damage followed by adverse LV remodeling, and lack of recovery of regional wall function. MVO has been reported to be a strong predictor of poor prognosis in STEMI patients. The relevance of MVO in Non-STEMI is unknown. Underlying athero-thrombotic processes resulting in NSTEMI are similar to those observed in STEMI, but always result in incomplete epicardial coronary vessel obstruction. Therefore myocardial ischemia in NSTEMI is less severe in NSTEMI than in STEMI’s, where full coronary obstruction is present.
Pressure controlled Intermittent Coronary Sinus Occlusion (PICSO) does reduce the level of MVO in patients with acute STEMI (data on file), thereby reducing infarct size. Thus, PICSO in patients with NSTEMI may represent a useful intervention, with the potential to improve patient prognosis.REC name
London - Stanmore Research Ethics Committee
REC reference
14/LO/1365
Date of REC Opinion
4 Nov 2014
REC opinion
Further Information Favourable Opinion