PICSO as an adjunct to PCI in acute coronary syndrome
Research type
Research Study
Full title
Pressure controlled Intermittent Coronary Sinus Occlusion as an adjunct to PCI in acute coronary syndrome. An observational study evaluating the effect of PICSO treatment concomitant to pPCI in patients with anterior non ST-segment Elevation Myocardial Infarction or following pPCI in ST-segment Elevation Myocardial Infarction.
IRAS ID
157608
Contact name
Azfar Zaman
Contact email
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
EudraCT number , 2014-003173-41
Research summary
Worldwide, coronary artery disease (CAD) is the single most frequent cause of death. Over 7 million people every year die from CAD, accounting for 12,8% of all deaths. Despite greater use of re-perfusion therapy, to try to restore the blood flow into the damaged tissue, such as use of primary percutaneous coronary intervention (pPCI), modern anti-thrombotic medications and secondary prevention treatments, mortality remains substantial with approximately 12% of patients dead within 6 months and with higher mortality rates in higher-risk patients. This justifies continued efforts to improve quality of care and the on-going quest for additional therapies. Although re-perfusion of the ischaemic myocardium is a pre-requisite for myocardial salvage, it has been described that the re-perfusion in itself may cause additional damage to the myocardium (re-perfusion injury). The obvious implication of this concept of re-perfusion injury is that adding adjunct therapies to early re-perfusion can salvage more myocardium. Pressure controlled Intermittent Coronary Sinus Occlusion (PICSO) aims to reduce or prevent re-perfusion injury. The purpose of this research study is to find out whether PICSO, as an adjunct to revascularisation in heart attack patients can reduce final infarct size and improve myocardial function as determined by cardiac MRI.
REC name
North East - York Research Ethics Committee
REC reference
14/NE/1129
Date of REC Opinion
25 Nov 2014
REC opinion
Further Information Favourable Opinion