Physiological response to physical activity in pulmonary hypertension
Research type
Research Study
Full title
Association of intensity of daily physical activity with respiratory response, central hemodynamics and leg muscle oxygen availability during exercise in Pulmonary Arterial Hypertension
IRAS ID
160508
Contact name
Martin K Johnson
Contact email
Sponsor organisation
NHS National Waiting Times Health Board
Research summary
This study will enrol stable patients with pulmonary hypertension (PH), a condition in which there is increased pressure within the pulmonary arteries causing progressive right heart failure and ultimately death. These patients have a reduced level of daily physical activity (DPA) which is linked to diminished health related quality of life. The relative contribution of impaired respiratory, haemodynamic and peripheral muscle dysfunction underlying the reduced DPA is not known because these measurements are not usually made at exercise intensities corresponding to normal DPA. Using non-invasive techniques this study will investigate the respiratory response (by measuring expired gases), the cardiac output (by bioimpedance) and the muscle oxygen saturation (by near infrared spectroscopy) at levels of exertion identified to correspond with the usual level of DPA for each subject. Using both multivariate linear regression and grouping of the subjects into those above and below median DPA levels, the best physiological predictors of impaired DPA will be identified This study will be the first to define physiological response to exercise in PH patients in conditions simulating real life activity levels. The investigations will be carried out at the Golden Jubilee National Hospital in Clydebank, where the Scottish Pulmonary Vascular Unit is based.
REC name
West of Scotland REC 3
REC reference
14/WS/1075
Date of REC Opinion
30 Sep 2014
REC opinion
Further Information Favourable Opinion