Physiological Effects of Isoeffective Colloid Vs Crystalloid Infusion

• Research type

  Research Study

• Full title

  The Effects of Isovolumetric and Isoeffective Infusions of Colloid Versus Crystalloid on Renal Blood Flow and Cardiac Output

• IRAS ID

  135895

• Contact name

  Dileep N Lobo

• Contact email

  dileep.lobo@nottingham.ac.uk

• Eudract number

  2013-003260-32

• ISRCTN Number

  na

• Clinicaltrials.gov Identifier

  na

• Research summary

  Restoration of blood volume after surgery or in critically ill patients can be achieved with either crystalloid or colloid infusions. However, it is clear that for a given volume, the blood volume expanding properties of colloids are superior to crystalloids. We aim to use novel, non invasive MRI techniques to test whether an infusion of a gelatin based colloid solution expands blood volume to a greater degree than an isovolumetric infusion of crystalloid, resulting in increased blood flow and perfusion to the kidneys as well as an increase in cardiac output.

• REC name

  East Midlands - Derby Research Ethics Committee

• REC reference

  13/EM/0363

• Date of REC Opinion

  6 Nov 2013

• REC opinion

  Further Information Favourable Opinion