Physiological changes following MIE in NMD
Research type
Research Study
Full title
Respiratory physiological changes following MIE (mechanical insufflation-exsufflation) in neuromuscular disease: Optimisation of pressure delivery
IRAS ID
191122
Contact name
Patrick Murphy
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
0 years, 5 months, 2 days
Research summary
This study aims to compare how the lung fills with air using three methods for clearing secretion(clearing mucus or phlegm from the airways), in order to determine the best way to clear secreations in patients with neuromuscular disease (NMD). \n\nPatients with NMD can suffer from a range of respiratory problems due to respiratory muscle weakness. Cough muscle weakness means secretion clearance from the airways can be problematic, and a source of infection. As a result, these patients are often supported with devices to aid clearance (such as mechanical insufflation-exsufflation, MIE) and reduce the risk of infection. Although evidence supports the use of these devices, the optimal technique or settings on the device are not clear. \n\nThis study will have two cohorts. The first is in NMD patients with evidence of respiratory muscle weakness, who are stable.. The second will include patients with NMD who are admitted to the Lane Fox Unit or Critical Care at St. Thomas’ Hospital, with an acute deterioration in their respiratory function, requiring physiotherapy to aid their secretion clearance. \n\nThe study protocol for both groups of patients will be the same. After being recruited into the study, they will undergo some simple non-invasive baseline measurements. They will then undergo three different methods of secretion clearance. Each method will last one hour, with 30 minutes between each method to allow the patient to rest. Throughout the testing stage, respiratory function will be monitored using non-invasive probes. \n\nEach patient will undergo approximately five hours of testing. The study will start in May 2016 and end in October 2016.\n
REC name
London - City & East Research Ethics Committee
REC reference
16/LO/0966
Date of REC Opinion
30 Jun 2016
REC opinion
Further Information Favourable Opinion