Physical Activity, Knee Joint Loading and Joint Health
Research type
Research Study
Full title
Investigating Physical Activity, Knee Joint Loading and Joint Health Following Anterior Cruciate Ligament Reconstruction
IRAS ID
304181
Contact name
Karl Morgan
Contact email
Sponsor organisation
University of Bath
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Approximately 50% of people will develop post-traumatic osteoarthritis (PTOA) 10-17 years after anterior cruciate ligament reconstruction (ACLR). PTOA is a subtype of osteoarthritis (OA) affecting the joint following injury. Alarmingly, most reconstruction surgeries conducted are on people aged under 40 years old, which may lead to a greater burden than typical osteoarthritis in years lived with the disease. In congruence, there are indications people with history of ACL injury undergo knee replacement surgery approximately 14 years earlier than those without in the United Kingdom (UK).
As rates of ACLR are increasing in various countries, including the UK, understanding the factors contributing to joint degeneration after injury are essential to help address the already increasing knee OA prevalence. Furthermore, a comprehensive characterisation of the reconstructed leg form and structure after ACLR is lacking. The proposed research seeks to establish if there is an association between physical activity, joint loading and joint health following ACLR, and to compare the leg form and structure between the reconstructed leg and the uninjured opposite leg.
To achieve this, men and women aged 18-39 (i.e., ≥18 and ≤39) who have had ACLR in the last one to seven (≥1 to ≤7) years will be recruited to undertake a cross-sectional study. All laboratory sessions will take place at a physiology laboratory (e.g., DisAbility Sport and Health Laboratory) and the Applied Biomechanics Suite located at the University of Bath.REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
22/SW/0004
Date of REC Opinion
15 Feb 2022
REC opinion
Further Information Favourable Opinion