Physical activity intervention and cardiovascular risk markers in COPD

• Research type

  Research Study

• Full title

  The effectiveness of a physical activity intervention versus pulmonary rehabilitation on cardiovascular risk markers for individuals with Chronic Obstructive Pulmonary Disease

• IRAS ID

  232477

• Contact name

  Sally Singh

• Sponsor organisation

  University Hospitals of Leicester NHS Trust

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  2 years, 0 months, 1 days

• Research summary

  The purpose of the study is to investigate the effectiveness of physical activity intervention with Chronic Obstructive Pulmonary Disease (COPD) patients compared with pulmonary rehabilitation programme in respect of cardiovascular risk markers. Investigation and data collection will be taking place within University Hospitals of Leicester sites. We are aiming to recruit 50 COPD patients who are legible for pulmonary rehabilitation programme to investigate the effect of physical activity intervention compared to pulmonary rehabilitation with respect to cardiovascular risks.
  The study will measure various outcomes, immediately before, immediately after interventions. These outcomes will include measures in aerobic fitness (walking test), strength tests, physical activity level, quality of life, breathlessness questionnaires. In addition, blood sampling and body measurements. we will also do a non-invasive test to measure the arterial stiffness which is a hardening of the artery wall. Arterial stiffness, when is considered as a cardiovascular risk marker. We have decided to test a large range of variables to gather as much information as possible and understand any change that may occur as a result of our intervention. The novelty is achieved by comparing the outcomes of physical activity intervention to pulmonary rehabilitation programme outcomes in respect to cardiovascular risk markers.
  In a subgroup study, 20 participants will have additional visits and measures. We will be doing magnetic resonance imaging (MRI), diagnostic pictures of the inside of the body we use it for picturing the fat tissue around the abdomen. MRI scanning is a non-invasive procedure. We will be also doing a postprandial lipaemic test which is testing the fat level in the circulating blood after a high-fat meal. We will do this test as before and after the intervention to allow for comparison. Postprandial lipaemia is one of the cardiovascular risk markers.

• REC name

  East Midlands - Leicester South Research Ethics Committee

• REC reference

  18/EM/0270

• Date of REC Opinion

  15 Nov 2018

• REC opinion

  Further Information Favourable Opinion