Physical activity in those with a family history of type 2 diabetes
Research type
Research Study
Full title
Characterising the metabolic disruption caused by brief periods of reduced physical activity in people with a family history of type 2 diabetes mellitus (T2DM)
IRAS ID
160152
Contact name
Daniel Cuthbertson
Contact email
Research summary
This research will investigate the relationship between genetic susceptibility for type 2 diabetes (T2DM) and physical activity levels. Individuals with a family history of T2DM often show pre-existing defects in blood glucose control and early stages of insulin resistance. In fact, those with a first degree relative suffering from the condition are three times more likely to develop it themselves when compared to those without diabetes relatives. It is known that regular physical activity and exercise have beneficial effects on cardiovascular and metabolic health; increasing activity is associated with reductions in the risk factors associated with diabetes such as poor blood glucose and insulin control, low cardiovascular fitness, reduced muscle mass and higher fat mass. However, the maladaptation’s to physical inactivity remain largely unexplored; an inactive lifestyle is emerging as an important risk factor for developing T2DM, however it is not known if the detrimental effects are greater in those with a genetic susceptibility for T2DM.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
14/NW/1147
Date of REC Opinion
8 Oct 2014
REC opinion
Further Information Favourable Opinion