Physical Activity Assessment Pre- and Post-Bariatric Surgery (0.2)
Research type
Research Study
Full title
Objective accelerometry-based assessment of day-to-day physical activity and magnitude of osteogenic vertical impacts prior to and following Bariatric surgery in postmenopausal females
IRAS ID
278649
Contact name
Will James Evans
Contact email
Sponsor organisation
University of Sunderland
Duration of Study in the UK
2 years, 6 months, 1 days
Research summary
Bariatric surgery is generally a safe and successful surgical intervention for severely obese individuals. However, harmful side-effects on bone and mineral metabolism (increased circulating calcium), leading to significant losses of bone tissue, and increased risk of fracture have been reported, particularly in post-menopausal females. Increasing physical activity (PA) prior to, and following Bariatric surgery has positive health benefits including; increasing weight-loss, improved insulin sensitivity, functional capacity, strength, and cardiovascular health. However, little is known about the effects of PA on bone in this cohort. Accelerometry is widely used to provide objective estimates of daily PA. The measures provide valuable information into the relationship between PA and health outcomes, and has also been used to quantify the relationship between PA (e.g. walking) and bone health, via vertical gravitational impacts (g) in older adults. To date, the size and number of vertical impacts, in a Bariatric population, has yet to be investigated. It is unclear if the vertical accelerations achieved will reach the desired osteogenic threshold. Quantifying the characteristics of daily bone loading in a cohort of post-menopausal females pre- and post- surgery would help in the development of effective exercise, and PA prescription which might improve bone health. Therefore, our initial aims are to; 1) assess the changes in the size and number of potentially osteogenic (bone forming) vertical impacts experienced prior to and following Bariatric surgery during day-to-day activity, 2) assess changes in functional movement, strength and biochemical markers (calcium, Vitamin D and parathyroid hormone) pre- and post-surgery, 3) assess the association between PA measures, and health outcomes including; body composition, strength, and biochemical markers, and 4) compare outcomes between the two surgeries (sleeve gastrectomy and Roux-en-Y gastric bypass). Physical activity will be measured for 7 days pre-, 3-, 6-, and 12-months post-surgery using an observational cohort design.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
20/SC/0321
Date of REC Opinion
24 Sep 2020
REC opinion
Further Information Favourable Opinion