Physical activity and brown adipose tissue
Research type
Research Study
Full title
THE PREVALENCE OF UNCOUPLING PROTEIN 1 GENETIC POLYMORPHISMS AND THEIR RELATIONSHIP WITH CARDIOVASCULAR METABOLIC DISEASE
IRAS ID
179343
Contact name
Giorgos Metsios
Contact email
Sponsor organisation
The Dudey Group NHS Foundation Trust
Duration of Study in the UK
1 years, 2 months, 23 days
Research summary
Cardio-metabolic disease (CMD) represents a heavy public health burden for Europe, as CMD prevalence in Eastern Europe is the highest globally with genetic and environmental factors being suggested as the primary contributors. Recently, a number of candidate genes were suggested as potential factors implicated in the pathogenesis of CMD. One of the reported candidates was uncoupling protein 1 (UCP1) due to its major role in metabolism. The main research objective of this study is to investigate specific variations of the UCP1 gene in a large group of CMD patients and healthy individuals as well as to investigate its association with physical activity levels and other health indices. Study design: This study will assess 500 individuals between the ages 15 and 59, 250 individuals with CMD i.e. type II diabetics, obese, or with metabolic syndrome and/or hypertension, and 250 healthy individuals. We want to assess individuals who are non-smokers, have no history of eating disorder, are not in a pregnancy and/or a lactation period, have no acute illness and/or infection the last 4 weeks. All participants will visit the laboratory once for less than 20 minutes in order to do the following assessments: a) Medical health history, b) physical activity questionnaire, c) measurement of blood pressure, height, weight, waist-to-hip ratio, body fat percentage, and d) taking one blood sample of 4 ml. The latter assessments will help up to investigate the variations of the UCP1 gene and its relationship with health indices. The participants will be recruited within the Clinical Research Unit at the Dudley Group NHS Foundation Trust and the Cardiology Department and the New Cross Hospital, Royal Wolverhampton Hospitals NHS Trust.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
15/NW/0874
Date of REC Opinion
12 Jan 2016
REC opinion
Further Information Favourable Opinion