PHYLLIS
Research type
Research Study
Full title
Prevent from Home: Young person and buddies’ cardiovascuLar heaLth Improvement feasibility Study (PHYLLIS)
IRAS ID
1008673
Contact name
Kate Bramham
Contact email
Sponsor organisation
King's College London
ISRCTN Number
ISRCTN17524311
Research summary
Heart attacks and strokes cause the greatest number of preventable deaths in the UK. People from ethnic minority
groups and those with socioeconomic deprivation are most severely affected. Women who develop high blood
pressure or diabetes during pregnancy are up to ten times more likely to develop these problems in later life. New
medications (Sodium glucose transport protein-2 inhibitors, SGLT2i) can prevent heart attacks, strokes and kidney
disease, they also reduce weight, blood pressure, and blood sugar but we do not know if they can prevent high blood
pressure and diabetes developing.Women find it very difficult to take part in research in the postnatal period, particularly those from ethnic minorities. We
have spoken to patients with lived experience of pregnancies complicated by high blood pressure and diabetes, in
addition to members of the public, and co-designed a study to ensure the design best supports postnatal
participation. The study involves:
- using ‘postpartum health champions’ to support women taking part in the study
- home-testing and digital data entry
- using of ‘study-buddies’ (a friend or family member with pre-diabetes or borderline high blood pressure) to support
women taking part in the study, in addition to increasing awareness and reassurance about research.PHYLLIS is a feasibility study of a randomised controlled trial which will compare outcomes of 108 women (and their
study-buddies) who take SGLT2i with women who do not, and explore different ways to support postnatal women
taking part in maternity research.REC name
London - South East Research Ethics Committee
REC reference
24/LO/0902
Date of REC Opinion
16 Jan 2025
REC opinion
Further Information Favourable Opinion