Photoreceptors in Diabetic Retinopathy
Research type
Research Study
Full title
Efficacy of High-Resolution Retinal Imaging and Detailed Psychophysical Assessment as Tools for Early Detection of Diabetic Retinopathy
IRAS ID
289911
Contact name
Emily J. Patterson
Contact email
Sponsor organisation
UCL
ISRCTN Number
ISRCTN00000000
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
Z6364106/2021/01/61, Data Protection Reference
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
Diabetic retinopathy (DR) is one of the most common causes of irreversible vision loss. Often, by the time a patient becomes aware of visual disturbances, significant damage to the retinal cells responsible our vision – cone and rod photoreceptors – has already occurred. There is therefore a need for effective screening and monitoring techniques to facilitate early detection, accurate diagnosis, and treatment of disease. Here we combine high-resolution imaging techniques with sensitive tests of colour vision and rod- and cone-mediated vision to determine whether DR can be detected during the earliest stages of disease. We further seek to explore whether there is a predictive relationship between these structural and functional measures.
This is a small-scale pilot study, with the aim of developing novel ideas and generating preliminary data that will facilitate larger grant applications.REC name
Wales REC 6
REC reference
21/WA/0152
Date of REC Opinion
14 May 2021
REC opinion
Further Information Favourable Opinion