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Phenotyping patients with elevated pulmonary arterial pressure

  • Research type

    Research Study

  • Full title

    Phenotyping individuals with elevated mean pulmonary arterial pressure and elevated pulmonary vascular resistance in the United Kingdom

  • IRAS ID

    275470

  • Contact name

    Gerry J Coghlan

  • Contact email

    gerry.coghlan@nhs.net

  • Sponsor organisation

    Royal Free London

  • Duration of Study in the UK

    0 years, 3 months, 1 days

  • Research summary

    This is a retrospective, observational, multi-center study, collecting data on patients with elevated mean pulmonary arterial pressure (mPAP) i.e the average blood pressure in the main pulmonary artery . This is measured using a cardiac catheter which is a long flexible tube inserted into a vein in the groin and fed through to the pulmonary artery. This measurement is used to confirm a diagnosis of pulmonary hypertension (PH) which is described as high blood pressure confined to the lungs. It is a lethal, debilitating, rare condition. mPAP above 25mmHG indicates PH.

    We will be collecting this data from patients that fall into three ranges: mPAP of <21mmHg, between 21-24mmHg and >25mmHg and comparing them to patients with borderline and normal mPAP. We will also be comparing clinical characteristics, biomarkers, therapies, quality of life (QoL), and prognosis with particular interest in the borderline cases, to better understand the natural progression of this disease.

  • REC name

    London - Harrow Research Ethics Committee

  • REC reference

    20/LO/0344

  • Date of REC Opinion

    23 Mar 2020

  • REC opinion

    Favourable Opinion