Phenotyping patients with elevated pulmonary arterial pressure
Research type
Research Study
Full title
Phenotyping individuals with elevated mean pulmonary arterial pressure and elevated pulmonary vascular resistance in the United Kingdom
IRAS ID
275470
Contact name
Gerry J Coghlan
Contact email
Sponsor organisation
Royal Free London
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
This is a retrospective, observational, multi-center study, collecting data on patients with elevated mean pulmonary arterial pressure (mPAP) i.e the average blood pressure in the main pulmonary artery . This is measured using a cardiac catheter which is a long flexible tube inserted into a vein in the groin and fed through to the pulmonary artery. This measurement is used to confirm a diagnosis of pulmonary hypertension (PH) which is described as high blood pressure confined to the lungs. It is a lethal, debilitating, rare condition. mPAP above 25mmHG indicates PH.
We will be collecting this data from patients that fall into three ranges: mPAP of <21mmHg, between 21-24mmHg and >25mmHg and comparing them to patients with borderline and normal mPAP. We will also be comparing clinical characteristics, biomarkers, therapies, quality of life (QoL), and prognosis with particular interest in the borderline cases, to better understand the natural progression of this disease.
REC name
London - Harrow Research Ethics Committee
REC reference
20/LO/0344
Date of REC Opinion
23 Mar 2020
REC opinion
Favourable Opinion