Phenotypic and genotypic characterisation of MDR pathogens
Research type
Research Study
Full title
Phenotypic and genotypic characterisation of multi-drug resistant pathogens
IRAS ID
352274
Contact name
Louis Grandjean
Contact email
Sponsor organisation
UCL Great Ormond Street Institute
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Antimicrobial resistance refers to when bacteria, viruses, fungi and parasites (bugs) no longer respond to antibiotic medicines. It has been estimated that, by 2050, 10 million deaths a year will be caused by antimicrobial resistance worldwide. For this reason, antimicrobial resistance has been characterised as global health emergency by the World Health Organisation.
In order to successfully manage resistant infections, novel antimicrobials are required that will have acivity against pathogens resistant to currently available last line agents. This study will focus on assessing recently licenced and upcoming antimicrobials for the treatment of multidrug resistant infections. It will characterise their in vitro suspeptibility using reference methods and perform whole genome sequencing to characterise mutations that confer resistance to new agents. Findings of this study will be used to inform treatment options for patients with multidrug resistant infections and describe mutations that confer resistance to new ly licenced antimicrobials, that could be of public health significance.
REC name
London - Queen Square Research Ethics Committee
REC reference
25/PR/0236
Date of REC Opinion
18 Mar 2025
REC opinion
Favourable Opinion