Peyronie's post-RALP
Research type
Research Study
Full title
The pathophysiology of Peyronie’s disease following radical prostatectomy
IRAS ID
289694
Contact name
David Ralph
Contact email
Sponsor organisation
UCL/UCLH Joint Research Office
Clinicaltrials.gov Identifier
151856, EDGE
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
In the general population the incidence of Peyronie’s disease (PD) is 0.7% rising to 16% of men having had a radical prostatectomy for a prostate malignancy(1, 2). In these men who already have a reported incidence of 50% erectile dysfunction (ED), post-surgery PD is a further complicating factor preventing sexual activity and impacting on their wellbeing (1). There is growing pre-clinical evidence to suggest that tissue hypoxia may be a significant contributing factor to the pathophysiology of PD following radical prostatectomy. It has also been suggested that men who developed ED after radical prostatectomy have low penile oxygen saturation(3) therefore prolonged penile hypoxia. Therefore, this study aims to test the hypothesis that the men who develop PD after a radical prostatectomy do so due to hypoxia within the penis and tunica.
This will be a prospective study recruiting men undergoing a radical prostatectomy at University College London (UCLH). Two groups will be recruited: 1. The RALP group: 30 men undergoing robotic-assisted laparoscopic prostatectomy (RALP) at the Prostate Cancer Clinic at UCLH excluding those who already have ED and PD prior to surgery. 2. Early PD group: 30 men who have been diagnosed with early PD but do not have prostate cancer.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
22/WM/0236
Date of REC Opinion
21 Nov 2022
REC opinion
Further Information Favourable Opinion