PET scanning in evaluation of vaccine reactogenicity; v1
Research type
Research Study
Full title
A pilot clinical study of PET scanning in evaluation of vaccine reactogenicity
IRAS ID
191407
Contact name
David Lewis
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
1 years, 6 months, 28 days
Research summary
PET (positron emission tomography) scans which use radioactive glucose as a tracer are used routinely for cancer imaging, because the signal is strongest in tissues which are highly metabolically active. We wish to use this technique to evaluate the timing and location of reactions to vaccination, which is known to induce metabolic activity at the vaccination site and nearby lymph nodes. We also wish to use a different PET tracer to identify whether macrophages are concentrated at the injection site and draining lymph nodes. Widely used, licensed vaccines will be used to induce reactions. We'll recruit up to 90 healthy men to be vaccinated. PET scans will be done up to 28 days after vaccination. We will also collect pre- and post-vaccination blood samples in order to study which biological molecules are involved in the response to vaccination.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
15/LO/2039
Date of REC Opinion
23 Dec 2015
REC opinion
Favourable Opinion