PET /MRI pre-RadiOtherapy for Post-Prostatectomy Salvage

• Research type

  Research Study

• Full title

  PROPS: PET/MRI pre-Radiotherapy for Post-Prostatectomy Salvage

• IRAS ID

  149856

• Contact name

  Sue Chua

• Sponsor organisation

  The Royal Marsden NHS Foundation Trust

• Research summary

  Successful salvage for men who are irradiated for biochemical recurrence after prostatectomy can vary between 20-70% depending in part on pre-radiation parameters. In particular men presenting with adverse features (i.e. negative surgical margins or pT3b or Gleason Grade > 8 at the time of initial prostatectomy; PSA >1.0 at the time of salvage radiotherapy or PSA doubling time < 10 months at the time of salvage radiotherapy) have a low success rate (<50%) with empirical salvage prostate bed radiotherapy, likely due to occult disease metastatic to regional nodes or distant sites not identified on conventional re-staging imaging. Improved imaging to select men for salvage radiotherapy is required to avoid futile treatment in men in whom recurrent disease is not confined to the prostate bed. This study seeks to determine if secondary staging with 18F-FCH PET following negative conventional imaging will provide additional information in identifying men with disease truly isolated to the prostate bed will benefit most from salvage radiotherapy directed to the prostate bed alone.
  

• REC name

  London - Chelsea Research Ethics Committee

• REC reference

  14/LO/1587

• Date of REC Opinion

  8 Oct 2014

• REC opinion

  Further Information Favourable Opinion