PET-MR imaging of coronary atherothrombosis
Research type
Research Study
Full title
Combined Positron Emission Tomography and Magnetic Resonance Imaging of Coronary Atherothrombosis
IRAS ID
234230
Contact name
Mhairi Doris
Contact email
Duration of Study in the UK
0 years, 9 months, 8 days
Research summary
Heart attacks remain a common cause of death in the United Kingdom and throughout the world. The most common
initiating event is the formation of a blood clot (thrombus) within the coronary arteries occluding blood supply to the
heart. However, we know that thrombus often occurs within the coronary arteries without causing any symptoms, and may be found in patients with stable angina. We wish to investigate whether thrombus within the coronary arteries can be detected in patients who have had a heart attack and in patients with stable angina using combined positron emission tomography and magnetic resonance (PET-MR) imaging. If possible, this may provide a safe and noninvasive means of identifying patients at higher risk of heart attacks.The study will be conducted in Edinburgh Heart Centre and participants will be recruited from the cardiology wards, outpatient clinics and day case unit. Participants will be asked to undergo a single PET-MRI scan and will subsequently undergo invasive angiography as part of standard care (non-research procedure). During the invasive angiogram procedure, an additional imaging test will be performed called Optical Coherence Tomography to provide images from within the heart blood vessels. A total of 40 participants will be recruited to this study.
REC name
South East Scotland REC 02
REC reference
17/SS/0154
Date of REC Opinion
15 Dec 2017
REC opinion
Favourable Opinion