PET CT analysis of restenosis after lower limb revascularisation
Research type
Research Study
Full title
Multi-modality imaging to determine the role of calcification and inflammation on restenosis rates following lower limb angioplasty / surgical bypass. The CIRLA Study.
IRAS ID
167667
Contact name
Patrick Coughlin
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
The prevalence of lower limb peripheral arterial disease (PAD) is high, classically affecting an older population and is associated with significant cardiovascular morbidity and mortality. The most common form of invasive treatment is angioplasty, where a balloon is passed down the artery from the femoral artery in the groin and stretches the narrowed part of the artery. Another form of revascularisation is infrainguinal arterial bypass surgery. The “Achilles Heel” of such procedures is restenosis.
The challenge for atherosclerosis imaging is to provide better prediction of such restenosis, to illuminate the underlying biology and to allow tracking of the initial atherosclerotic plaque's response to therapy.
Work pioneered in Cambridge has shown that non-invasive imaging with positron emission tomography/computed tomography (PET/CT) using the tracers 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF), can reproducibly quantify plaque inflammation and can be used to monitor the effect of therapies on atherosclerosis with 18F-NaF specifically able to identify high risk coronary plaques.
This study will investigate the relationship between arterial inflammation (18F-FDG) and calcification (macro calcification / 18F NaF) in the lower limb arterial tree before and after an angioplasty procedure or surgical bypass and to link such processes to the mid term risk of restenosis.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
15/EE/0153
Date of REC Opinion
10 Sep 2015
REC opinion
Further Information Favourable Opinion