Peritoneal drain fluid lactate and pH after colorectal surgery - v1
Research type
Research Study
Full title
Can the serial measurement of pH and lactate in peritoneal drain fluid predict anastomotic leak after colorectal surgery?
IRAS ID
210376
Contact name
Emma C Wright
Contact email
Sponsor organisation
NHS Greater Glasgow and Clyde
Duration of Study in the UK
0 years, 9 months, 19 days
Research summary
Anastomotic leak after colorectal surgery can lead to significant morbidity and mortality. It is difficult to predict and detect, the diagnosis is often delayed. Previous research has looked at the use of measuring various substances (e.g. cytokines, bacteria, pH, lactate) from peritoneal drains following colorectal surgery to predict anastomotic leak. One study has had good results when looking at pH - a low pH on day 3 post-op was predictive of anastomotic leak. Other studies have looked at lactate but have measured it using a complicated technique called micro-dialysis. Our overall aim is to create a device that can be left in the abdomen after surgery that measures various substances and can give an early warning of a leak. In order to do this we need to decide which substances to measure. We aim to see if the results for peritoneal drain pH can be replicated and will look at lactate when measured from a peritoneal drain. Patients who have drains left in following surgery (this is at the discretion of the surgeon) will have pH and lactate levels measured daily until the drain is removed (normal practice is to empty the drains each day and discard the contents of them). We will record whether or not the patient develops a leak and determine if the pH and lactate levels from the drain are predictive of this.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
16/EM/0394
Date of REC Opinion
2 Sep 2016
REC opinion
Favourable Opinion