Peritoneal Biomarker Project
Research type
Research Study
Full title
To assess the transcriptomic and biomarker concordance between primary colorectal cancer and peritoneal metastasis
IRAS ID
260443
Contact name
Omer Aziz
Contact email
Duration of Study in the UK
0 years, 7 months, 10 days
Research summary
There is limiting literature and variable results on whether there is transcriptomic concordance between primary and metastatic colorectal cancer. A transcriptomic analysis looks at the genes that are actively expressed in the tumours, a genomic analysis looks directly at the DNA sequence for mutations. The current studies available focus on the liver as a metastatic site and very few have analysed peritoneal metastases (metastatic spread to the lining of the abdominal cavity). The peritoneum is one of the top three sites of colorectal cancer metastasis and patients tend to have a poorer overall survival and more information is needed to better understand the disease in order to improve this poor statistic.
This research project aims to test whether there is any concordance between primary colorectal cancer and its paired peritoneal metastatic site for the following variables:
- Transcriptomic analysis
- Biomarkers
Hopefully the findings will improve our understanding of peritoneal disease and provide useful clinical information on the management of this advanced disease state.REC name
London - Queen Square Research Ethics Committee
REC reference
19/LO/1339
Date of REC Opinion
14 Aug 2019
REC opinion
Further Information Favourable Opinion