Peri-haematomal oedema in ICH study
Research type
Research Study
Full title
The relationship between peri-haeamtomal oedema, C-reactive protein and outcome: analysis of an international, multi-centre, prospective intracerebral haemorrhage cohort.
IRAS ID
186552
Contact name
Adrian Parry-Jones
Contact email
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
A stroke caused by a spontaneous bleed within the brain is called intracerebral haemorrhage (ICH). It affects 10-25 people per 100,000 annually and accounts for 10-20% of all strokes. ICH has the worst outcome of all strokes. Up to 40% of patients do not survive beyond one month and of those surviving, less than half regain independence.
A common complication of ICH is swelling of the brain tissue around the blood clot; perihaematomal oedema (PHE) which causes the brain to swell within the skull, leading to increased pressure, reduced conscious level and impaired neurological function. PHE is often present early after ICH and can be seen on early brain scans but it can increase rapidly in the first few days and then more slowly for up to two weeks before peaking. There is a lack of understanding amongst doctors as to whether PHE on its own leads to a worse outcome after ICH. Recent studies have not fully answered this question, as they have not looked at PHE beyond 24 hours after ICH. We know that the body also responds to injury such as ICH by releasing proteins which cause inflammation and this project aims to understand the relationship between inflammation, PHE and survival after ICH by addressing the following specific research questions:
Is there an association between levels of inflammation in the blood and extent of PHE immediately following ICH?
Is there an association between levels of inflammation in the blood and the rate of PHE growth over the first 7 days after ICH?
Is there an association between the number of white blood cells in the blood and the rate of PHE growth over the first 7 days after ICH?
Does the extent of perihaematomal oedema at presentation or the rate of growth over the first 7 days after ICH predict survival to 30 days?REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
15/EM/0368
Date of REC Opinion
12 Aug 2015
REC opinion
Favourable Opinion