Perfusion mapping in ischaemic heart disease and cardiomyopathy
Research type
Research Study
Full title
An observational cohort study to investigate the accuracy and reproducibility of myocardial perfusion mapping in the assessment of coronary artery disease and cardiomyopathy.
IRAS ID
217617
Contact name
James Moon
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
3 years, 0 months, 4 days
Research summary
Coronary artery disease (CAD) is narrowing of the blood vessels that supply the heart. This reduces the blood flow to heart muscle. Cardiovascular magnetic resonance imaging (CMR) is a way to look at the heart without exposing patients to radiation or needing surgery. A chemical is used to stress the heart and pictures are created to tell us if the heart muscle receives enough blood when it’s under stress. Interpreting these results can be difficult because it has not until now been possible to measure how much blood flow there is to the heart muscle, we can only tell that one part of the heart has less blood flow than another. We've developed a way to measure the blood flow to the heart muscle (known as myocardial perfusion) with CMR. We will study this in healthy volunteers, patients with CAD and other patient groups where perfusion reserve may be low and treatable.
We aim to show that our method is reproducible,accurate and with reduced variability between doctors analysing the results. We aim to investigate whether knowing the blood flow to a region of the heart improves the detection of disease in the arteries of the heart. We aspire that a safe, readily available and affordable method of measuring blood flow to heart muscle can be used to help patients by improving the detection of significant disease in the arteries of the heart. This may help better identify those who need treatment.
REC name
South Central - Hampshire B Research Ethics Committee
REC reference
17/SC/0077
Date of REC Opinion
15 Feb 2017
REC opinion
Favourable Opinion