Perfusion imaging in presumed Diffuse Midline Pontine Glioma
Research type
Research Study
Full title
Perfusion and Diffusion Imaging in Presumed Paediatric Diffuse Midline Glioma of the Pons: a UK regional analysis.
IRAS ID
275469
Contact name
John-Paul Kilday
Contact email
Sponsor organisation
Manchester University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 4 months, 0 days
Research summary
Childhood diffuse midline gliomas (H3K27 mutant) of the pons, formerly diffuse intrinsic pontine gliomas, have historically been diagnosed using characteristic magnetic resonance imaging (MRI) metrics without histological confirmation. Tissue analysis of pontine tumours in the molecular era has evolved, resulting in a proportion of diffuse midline gliomas being re-diagnosed as embryonal tumours; lesions with contrasting management and potential patient outcomes. Simultaneously, modern neuro-imaging now incorporates multi-parametric physiological assessments including perfusion and diffusion sequences. We postulated whether integrating modern multi-parametric imaging could discriminate between such tumour types at presentation. We will perform a population-based review of children with presumed diffuse midline glioma (pons) at Royal Manchester Children’s Hospital and Alder Hey Hospital Liverpool, from 2012 - 2019 . Diagnostic MRI scans will be evaluated, including diffusion and perfusion weighted sequences. Tumour histopathology, molecular biology, patient demographics, therapy and survival data will also be collated.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
20/EE/0053
Date of REC Opinion
19 Mar 2020
REC opinion
Further Information Favourable Opinion