Perceptual response to loading in Obstructive Sleep Apnoea version 1
Research type
Research Study
Full title
Perception of effort and patterns of muscle recruitment during fatiguing inspiratory and limb muscle exercise in patients with Obstructive Sleep Apnoea (OSA).
IRAS ID
210056
Contact name
Claire L. Griffith-Mcgeever
Contact email
Sponsor organisation
School of Sport, Health, and Exercise Sciences
Clinicaltrials.gov Identifier
17/EM/0162,
Duration of Study in the UK
1 years, 3 months, 6 days
Research summary
Obstructive Sleep Apnoea (OSA) is the most common sleep disorder in the UK, characterised by multiple episodes of partial or complete narrowing of the upper respiratory airways during sleep. Besides severe daytime sleepiness, OSA has an independent association with hypertension, cardiovascular disease, type 2 diabetes and stroke. However, the disease process in OSA is not fully understood. Our recent research in collaboration with the Pulmonary Function and Sleep Units at Ysbyty Gwynedd, revealed that the severity of OSA is associated with; the breathing response to carbon dioxide (as a measure of the sensitivity of the breathing control system of the brain), and the effort perception during repeated inspirations against a resistance (as a measure of the fatigability of the inspiratory muscles). These results suggest that the respiratory muscles and the respiratory sensitivity to carbon dioxide is affected in OSA. In this current project, we will further our investigations to gain more understanding of the OSA disease process for the development of future treatment schemes.
Newly diagnosed OSA patients will be recruited, and their effort perception in response to repeated inspirations against a load recorded, during which the electrical activity of the inspiratory and some accessory muscles will be measured. The breathing manoeuvre will be performed in a seated and supine posture to understand the fatigability of the breathing muscles and the support of accessory muscles. In addition, effort perception during repeated leg exercise will be measured to record the overall muscular fatigability in OSA patients. The sensitivity to breathing carbon dioxide will be assessed with the recently established protocol. Data will enable us to understand whether OSA severity is associated with localised alterations in muscle quality or more generalised changes in fatigability, as well as the contribution of altered sensitivity of the breathing system. Data from healthy individuals has been collected for comparison with OSA data.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
17/EM/0162
Date of REC Opinion
24 May 2017
REC opinion
Further Information Favourable Opinion