PEONY STUDY
Research type
Research Study
Full title
Functional and structural phenotypes in genotypes at varying risk for age related macular degeneration
IRAS ID
259845
Contact name
Sobha Sivaprasad
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106, UCL Data Protection Registration Number
Duration of Study in the UK
2 years, 1 months, 31 days
Research summary
This project will study the changes in retinal function and structure in willing participants who have low, medium or high-risk genotype of age related macular degeneration (AMD). AMD is a heterogeneous disease which means it can present with various signs in early disease but at present they are collectively called AMD. Many drugs that are developed for preventing or treating AMD have failed because because the drugs are tested in a heterogeneous population with AMD. We also know changes in certain genes are more likely to cause AMD and yet we do not understand the link between the genes and AMD. By studying the changes of the retina caused by abnormal genes, we may be able to carefully divide AMD into groups that will more logically explain why some genes cause retinal changes and this will in future help to target the new drugs to the correct AMD groups. In this study, a total of 500 people will be recruited. They will include people with AMD, their family members who are aged 40 years or above, or participants of the Genomics England Project or NIHR Bioresource who have already donated their blood sample for genetic testing and have consented for re-call for future research projects. They will be invited for this study in Moorfields Eye Hospital. Participants will have visual function and retinal imaging tests and the findings will be correlated to identify AMD groups. The participants will be genotyped in the project or have been previously genotyped and will be of 3 groups -low risk, medium risk or high risk genotype but the retinal researchers and the participants will be masked of individual genotype. The genotype group will be correlated to the AMD groups to understand the relation of genotypes with the retinal changes.
REC name
London - Chelsea Research Ethics Committee
REC reference
19/LO/0931
Date of REC Opinion
24 May 2019
REC opinion
Further Information Favourable Opinion