PD-PCOS
Research type
Research Study
Full title
Prediction of Diabetes in women with Polycystic Ovary Syndrome using an epigenetic approach (PD-PCOS)
IRAS ID
163859
Contact name
Pensee Wu
Contact email
Sponsor organisation
Research and Development Department
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
We wish to explore if there is evidence that an epigenetic signature exists which discriminate polycystic ovary syndrome (PCOS) women with type 2 diabetes mellitus (T2DM) from PCOS women without T2DM. As a secondary aim, we will compare the candidate genes, which form a part of the identified epigenetic signature, with existing literature to see whether any genes overlap with those previously implicated in T2DM and validate these genes. Our longer term aim is to identify an epigenetic signature that predicts T2DM in PCOS patients.
We will take blood samples from 12 women with PCOS and T2DM, and 12 women with PCOS only as controls. Clinical data such as year of PCOS diagnosis, age, and body mass index will be recorded. DNA will be extracted from the blood samples and used to examine the difference in methylation patterns between the 2 groups of women.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
15/EM/0080
Date of REC Opinion
9 Feb 2015
REC opinion
Unfavourable Opinion