PD Gut Microbiota

• Research type

  Research Study

• Full title

  Characterization and Modulation of Gut Microbiota in a multiethnic dialysis cohort using the Diabetic Kidney Centre Biobank: a feasibility and Pilot Study

• IRAS ID

  319628

• Contact name

  Stanley Fan

• Contact email

  f.stanley@nhs.net

• Sponsor organisation

  Barts Health NHS Trust

• Duration of Study in the UK

  1 years, 4 months, 1 days

• Research summary

  The Diabetic Kidney Centre (DKC) BioBank can identify samples already donated by Peritoneal Dialysis patients. The DKC IT staff will interogate the DKC-Registry to identify serial samples donated when patients did not have change to laxatives (Control Group) and those who donated after starting lactulose (a commonly used laxatives). We want to know if Gut Microbiome (bacteria) are stable in the Control patients and whether the is increase in "good" bacteria after starting lactulose which is a fermentable fibre. We can also extract blood already donated by these patients to see if changes in microbiome improves insulin resistance.

• REC name

  South West - Central Bristol Research Ethics Committee

• REC reference

  24/SW/0011

• Date of REC Opinion

  3 Jan 2024

• REC opinion

  Favourable Opinion