PCS-Mx
Research type
Research Study
Full title
Non-invasive measurement of cerebral blood flow regulation in post-concussive syndrome-like presentations: Feasibility & Correlations
IRAS ID
266210
Contact name
Adel Helmy
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge
Duration of Study in the UK
0 years, 11 months, 25 days
Research summary
Post-concussive syndrome (PCS) refers to a combination of physical and mental symptoms that are most frequently described after mild traumatic brain injury (TBI). These symptoms include headache, dizziness, difficulty concentrating, memory problems, depression and anxiety. It can occur in 11-82% of patients after TBI but its true occurrence rate is poorly understood. Similarly, the underlying cause of PCS is unclear and heavily debated - although there are many theories for this. The same cause exists for post-traumatic dizziness and vertigo, in which scans and other specialised tests can be normal, yet the patient is still symptomatic.
One theory suggests a disturbance in the blood flow within the brain might be the cause. Previous studies with smaller groups of patients have tested this theory and found promising results. The brain blood flow can be accurately estimated using a finger probe blood pressure sensor and an ultrasound scan of one's head.
We hope to measure brain blood flow control using the methods above in patients with symptoms of PCS and post-traumatic dizziness and vertigo and compare the results to asymptomatic patients and healthy volunteers. We hope to investigate whether there are any differences that could explain why these symptoms develop, aiming to inform future studies and treatment strategies.
To support this, we will also test the participant's brain function (using a brain training style app - used extensively for research) and ask them to complete questionnaires about their symptoms and how they affect their lives. Routine blood tests will be also be taken to look for signs of inflammation and to get an idea of overall health. Finally, we will also perform routine measurements that test the functions of ears and their balance.
This will all take place in study clinics - the logistics of which are discussed later (A13).
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
19/SC/0444
Date of REC Opinion
13 Sep 2019
REC opinion
Further Information Favourable Opinion