PC -TOX
Research type
Research Study
Full title
Cancer Treatment Related Cardiovascular Toxicity- Comprehensive Myocardial and Vascular Phenotyping
IRAS ID
297367
Contact name
Charlotte Manisty
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2021/06/238 , UCL DPN
Duration of Study in the UK
10 years, 1 months, 1 days
Research summary
Cancer is a big health problem and affects half of all people during their lifetime. People are now living longer with cancer because of improved treatments. Unfortunately, it is now known that cancer patients are at greater risk of heart disease compared to those without, often because of side effects of cancer treatments. There are many groups of cancer treatments that affect the heart and they do so in various ways. In some cases we do not completely understand how they lead to heart and blood vessel complications. Some complications include heart attacks and heart failure and if these happen then patients have to change onto alternative (potentially less effective) treatments. We want to change this.
We will study a group of patients starting chemotherapy and use a heart MRI scan to measure the blood flow in the heart before and during treatment and use other cameras to measure the blood vessels in the rest of the body including the arteries of the heart and eyes.
With this research we hope to identify how these medications affect the heart and find ways to detect problems early before patients have severe complications. In the future this information will help us to test drugs to prevent these complications, thereby improving both cancer and heart outcomes.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
21/LO/0744
Date of REC Opinion
3 Nov 2021
REC opinion
Favourable Opinion