Patterns of peritoneal dissemination and response to Chemotherapy
Research type
Research Study
Full title
Patterns of peritoneal dissemination and response to systemic chemotherapy in common and rare peritoneal tumors treated by cytoreductive surgery: A prospective, multi-center, observational study
IRAS ID
296294
Contact name
Faheez Mohamed
Contact email
Sponsor organisation
Hampshire Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
Clinicaltrials.gov Identifier
Clinical Trials Registry of India, CTRI/2020/09/027709; RENAPE observational registry, CNIL - no. DR-2010-297; BIG-RENAPE registry, NCT NCT02823860
Duration of Study in the UK
5 years, 7 months, 14 days
Research summary
Major surgery and administration of heated chemotherapy is the mainstay treatment for rare cancers that develop in or spread through the lining of the abdomen called the peritoneum. The surgery is called cytoreductive surgery (CRS). Despite optimal patient selection and surgical effort, recurrence is seen in a majority of patients undergoing cytoreductive surgery for peritoneal metastases (PM) with the peritoneum being the most common site of recurrence. Apart from the Peritoneal Cancer Index (PCI), completeness of the operative procedure and tumour grade, there are other factors like disease distribution in the peritoneal cavity, response to systemic chemotherapy(SC), lymph node spread and morphology of PM which may have prognostic value. These factors are underutilized because they are known only after surgery. Identifying clinical predictors, specifically radiological predictors, could lead to better utilization of these factors in clinical decision making and guide the extent of surgical resection performed for different tumours. This study aims to identify and study these factors and their impact on patient survival.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
22/SC/0076
Date of REC Opinion
22 Mar 2022
REC opinion
Favourable Opinion