Patient circadian disruption v.1

• Research type

  Research Study

• Full title

  Evaluation of circadian disruption in patients

• IRAS ID

  311421

• Contact name

  J F Blaikley

• Contact email

  john.blaikley@manchester.ac.uk

• Sponsor organisation

  University of Manchester

• Duration of Study in the UK

  5 years, 0 months, 1 days

• Research summary

  Background: Physical changes happen to people over the course of the day in a cyclical manner. e.g body temperature and wakefulness. These daily changes are called circadian rhythms and affect how the body responds to challenges e.g. infection or disease. Unfortunately, we do not understand much about what drives these rhythms and what their consequences are despite it affecting about 50% of patients. This is because it is very difficult to measure these rhythms and the mathematical modelling can be quite complex. Generating high quality data will therefore help to answer some fundamental questions.
  Who: We are therefore planning to measure circadian rhythms in adult patients to see if these are altered in disease

  Where: This study will take place in an NHS setting

  How: Blood samples will be taken from patients during their stay over 2 days. These will then be analysed in the laboratory (NHS, University or commercial) to tell us how the “body clock” is ticking and what changes have been caused by disease. In addition to blood samples saliva and urine may also be taken since this may be able to refine the body clock assays further. In addition to measuring the body clock the clinical consequences will also be identified through measurement of mediators in the blood and analysis of clinical records.

  This will allow us to assess importance of various causes which drive circadian disruption and define their clinical associations.
  

• REC name

  North West - Greater Manchester South Research Ethics Committee

• REC reference

  22/NW/0067

• Date of REC Opinion

  4 Apr 2022

• REC opinion

  Further Information Favourable Opinion