PATH-VHD
Research type
Research Study
Full title
PATHological changes in the cardiovascular system in Valvular Heart Disease
IRAS ID
275360
Contact name
Thomas Treibel
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
5 years, 0 months, 0 days
Research summary
We are planning an observational cohort study of patients recruited from Barts Heart Centre presenting with valvular heart disease. The specialized investigations will focus on myocardial remodeling and scar formation/regression and extracardiac micro- and macro-vascular sequelae of valvular heart disease (VHD). The aim is to investigate the natural history of VHD and its ensuing cardiac and extracardiac end organ effects, the impact of existing interventions and the long-term outcome. We hope to establish the underlying causative aetiology of known associated conditions (e.g. vascular dementia) and to determine if extracardiac changes may serve as early biomarkers of prognosis in VHD. Participants will attend for two visits at Barts Heart Centre and will undergo a panel of tests including cross-sectional cardiac imaging, point-of-care microvascular assessment and blood tests. Patient outcome will be assessed by data linkage to hospital episode statistic (HES) data and ONS data (via NHS spine). WE aim to identify determinants that will help to improve patient selection and timing of valve intervention based on advanced clinical, blood and/or imaging biomarkers.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
20/SC/0424
Date of REC Opinion
6 Jan 2021
REC opinion
Further Information Favourable Opinion