PAROS
Research type
Research Study
Full title
Postoperative Anaemia Recovery after Orthopaedic Surgery (PAROS): an observational prospective cohort study
IRAS ID
268451
Contact name
Antony Palmer
Contact email
Sponsor organisation
University of Oxford / Clinical Trials and Research Governance
Duration of Study in the UK
1 years, 3 months, 1 days
Research summary
There has been little research into the effect of anaemia (decreased haemoglobin levels) after hip and knee replacement surgery on patient on-going health. Research has mainly focused on the effect of anaemia before surgery, which has shown to be associated to adverse events following major orthopaedic surgery. However, preliminary studies have shown that anaemia after surgery may also be associated with an increased risk of adverse events. Adverse events such as heart attack and stroke often occur during this post-surgery period, which may be due to reduced oxygen reaching tissues and organs in the body. Furthermore, patients with anaemia may feel more fatigued, limiting their mobility and increasing the risk of complications after surgery.
Patients may lose over two litres of blood following hip or knee replacement surgery and over 90% of patients are anaemic postoperatively. Recent changes to blood transfusion guidelines in the UK, restrict transfusions in order to reduce transfusion associated risks and has led to increased number of patients being discharged with more severe anaemia.
This research study aims to better understand the relationship between anaemia after hip or knee replacement surgery and on-going patient health. We plan to develop a clinical tool which will enable the prediction of patients who might be at risk from persistent anaemia after their surgery. The study will also help to inform a larger clinical trial looking at potential treatment options, such as iron supplementation, after surgery. We plan to recruit 300 participants undergoing hip or knee replacement surgery and follow them up for up to 90 days after their surgery.REC name
London - Chelsea Research Ethics Committee
REC reference
19/LO/2011
Date of REC Opinion
11 Feb 2020
REC opinion
Further Information Favourable Opinion