PARIS
Research type
Research Study
Full title
Pneumonia: Acute Respiratory Infection ± Sepsis
IRAS ID
269427
Contact name
Ben Creagh-Brown
Contact email
Sponsor organisation
Royal Surrey County Hospital
Duration of Study in the UK
1 years, 6 months, 7 days
Research summary
The commonest type of chest infection that requires patients to stay in hospital is pneumonia. People are increasingly aware of ‘sepsis’ and pneumonia is the commonest cause of this. Pneumonia is also the leading cause of death from an infection and hospitalisation due to pneumonia is increasingly common. More than 20,000 people in the UK were admitted to intensive care in 2015/6 and one third of them died during that hospital stay. Those who leave hospital after pneumonia suffer prolonged ill health and many become increasingly frail and get repeatedly readmitted to hospital. The sicker they are in hospital, the worse their outcomes are – even up to 6 years later. It is plausible that during the acute illness the immune system sustains some permanent damage.
This is an observational study that aims to recruit hospitalised patients with pneumonia and obtain blood from them to look at quicker and more accurate ways of diagnosing pneumonia (and sepsis). A second aim of this study is to establish if some survivors need more help looking after themselves and if this relates to persistent inflammation. The data obtained from this study will help identify potentially modifiable factors to help us design a future trial to intervene and improve patient outcomes.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
20/SC/0006
Date of REC Opinion
16 Nov 2020
REC opinion
Further Information Favourable Opinion