Paradoxical Lucidity in Severe End-Stage Dementia

• Research type

  Research Study

• Full title

  Paradoxical Lucidity in Severe End-Stage Dementia: A Mixed Method Prospective Study

• IRAS ID

  345598

• Contact name

  Charles D. Deakin

• Contact email

  charlesdeakin@doctors.org.uk

• Sponsor organisation

  NYU Langone Health

• Clinicaltrials.gov Identifier

  NCT05234866

• Duration of Study in the UK

  2 years, 6 months, 1 days

• Research summary

  Cognitive decline in dementia is considered irreversible; however, episodes of paradoxical lucidity (PL) in advanced dementia suggest other mechanisms may be in play. Beyond anecdotal reports of transient PL events occurring in patients predominantly in late-stage dementia, typically lasting anywhere from a few minutes to several hours, we know little about PL. We propose to conduct a mixed methods prospective study of PL in people with advanced dementia, creating a definition and measurement scale for PL, and identifying the potential electrocortical biomarkers of PL in people with advanced dementia.

• REC name

  Wales REC 1

• REC reference

  24/WA/0202

• Date of REC Opinion

  14 Aug 2024

• REC opinion

  Unfavourable Opinion