PANTHER
Research type
Research Study
Full title
Precision medicine Adaptive Network platform Trial in Hypoxaemic acutE respiratory failuRe
IRAS ID
1008743
Contact name
Daniel McAuley
Contact email
Sponsor organisation
Imperial College London
ISRCTN Number
ISRCTN81435672
Research summary
Acute Respiratory Distress Syndrome (ARDS) is a common severe lung condition in the intensive care unit (ICU) that makes it hard to breathe. Inflammation is a natural process that helps our body fight off harmful substances like infections. However, sometimes it can go into overdrive and damage the lungs. About 1 out of every 4 people in the ICU who need a machine to help them breathe (a ventilator) have ARDS. ARDS causes significant death and disability. There are no proven effective medicines to treat it.
We have identified two subgroups of patients with ARDS. We can identify these subgroups by measuring certain substances in the blood. Patients from each subgroup are likely to respond differently to some treatments. We want to be able to identify which patients with ARDS will respond best to a treatment to improve patient care.
We are planning a “platform” clinical trial to test different treatments for ARDS. This type of trial tests several treatments at the same time in a group of people. This means we can find what works and is safe, with the smallest number of patients. We can also test additional treatments during the trial as new information emerges. We hope that this way of testing treatments will help us find effective treatments for ARDS as quickly as possible and save money.
We will start by testing 2 treatments, that are safe and are widely used for other conditions. There is evidence that they may work for ARDS.
We will measure how many patients survive and how long it takes survivors to recover. We plan to conduct this research in multiple countries worldwide.REC name
North West - Liverpool Central Research Ethics Committee
REC reference
25/NW/0103
Date of REC Opinion
27 Jun 2025
REC opinion
Further Information Favourable Opinion