PanIQoL Study
Research type
Research Study
Full title
A study to determine the relationship between systemic inflammation, quality of life and accelerated ageing in chronic pancreatitis
IRAS ID
171678
Contact name
Stuart Robinson
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Chronic pancreatitis is an inflammatory condition affecting the pancreas gland which as it progresses leads to destruction of healthy pancreatic tissue which is subsequently replaced by scar tissue. This results in the loss of key pancreatic functions including the production of enzymes necessary to absorb nutrients in the diet, leading to malnutrition, and secretion of hormones necessary for control of blood sugar levels which can lead to the development of insulin dependent diabetes. In addition the scar tissue in the pancreas can lead to patients developing debilitating chronic pain.
It is not surprising that chronic pancreatitis is associated with a reduction in quality of life. In addition this condition is associated with an increased risk of developing heart and lung disease and has been associated with a reduction in life expectancy by almost 10 years.
Over recent years there has been a growing recognition that a chronic low grade systemic inflammatory state can lead to the development of a variety of disease linked to accelerated ageing – a process known as “inflamm-ageing”. Whilst it seems intuitive that such a state exists in chronic pancreatitis sufferers such a link has never been demonstrated.
The aim therefore of this study is to determine what association, if any, exists between a diagnosis of chronic pancreatitis and the presence of systemic inflammation. In addition we will determine the relationship between this and accelerated ageing and patient reported quality of life.REC name
London - Chelsea Research Ethics Committee
REC reference
15/LO/0348
Date of REC Opinion
4 Mar 2015
REC opinion
Further Information Favourable Opinion