Pancreatic Cancer Research Fund Tissue Bank v3

• Research type

  Research Tissue Bank

• IRAS ID

  330071

• Research summary

  Pancreatic Cancer Research Fund Tissue Bank (PCRFTB)

• REC name

  South Central - Hampshire B Research Ethics Committee

• REC reference

  23/SC/0282

• Date of REC Opinion

  29 Aug 2023

• REC opinion

  Favourable Opinion

• Data collection arrangements

  Pancreatic Cancer Research Fund Tissue Bank (PCRFTB) aims to collect samples of blood, urine, saliva from patients with suspected pancreatic problems. Furthermore, tumour and normal tissue, from those patients undergoing an operation to remove tissue from different types of pancreas diseases will be asked to donate tissue. Donation to the PCRFTB will not alter the treatment of the patient in any way. All donors will also be asked to provide written consent for PCRFTB to collect and store information from their medical records. In order to participate they must also consent for this information to be shared with researchers in a pseudo-anonymised way.

  Samples will be collected at multiple national centres, the Co-ordinating Centre is Barts Cancer Institute, Queen Mary University of London. Prospective donors will be given an information sheet explaining samples/data collected and type of research to be carried out on samples collected and there right to consent or to withdraw samples any time. Consent will be obtained by Clinicians, Research Nurses or designated trained professionals during routine hospital clinics.

  PCRFTB is national only tissue bank of its kind developed exclusively for collaborative research to improve the standard of pancreas cancer research in the UK for the benefit of pancreas cancer patients. The PCRFTB is licensed by the Human Tissue Authority (licence 12199) to store human tissue for research and has ethics approval from the Research Ethics Committee (Renewal pending) to collect and store and distribute samples for cancer related research.

• Research programme

  A wide range of clinical, basic and translational research programs will be undertaken by scientists and doctors and their teams (clinical and non-clinical academics and undergraduates/ post graduate students). The aim is to develop new diagnostic and therapeutic tests for pancreatic cancer and other diseases. This will include examination of anonymised patient data alongside pathological and molecular / biochemical analysis of tissues, urine, blood, saliva, normal and diseased tissues. A range of modern molecular pathological and laboratory techniques will be employed. These include state of the art analysis for changes in DNA, RNA, proteins and cell types. The aim would be to generate new diagnostic tests for patients as well as aid in therapy development. Cell lines will be developed from tissues to enable greater understanding of different cell types in distinct diseases. The data generated from these research programs will include, but not restricted to gene expression profiles, biomarker profiles and image etc. Understanding of the basic molecular mechanisms in normal and diseased tissue will lead us to develop new treatments for cancer patients.

• Storage license

  12193

• RTBTitle

  Pancreatic Cancer Research Fund Tissue Bank (PCRFTB)

• Establishment organisation

  Barts Cancer Institute, Centre for Tumour Biology

• Establishment organisation address

  John Vane Science Centre

  Charterhouse Square

  London

  EC1M 6BQ