PAMPA
Research type
Research Study
Full title
Prevalence of asymptomatic malaria in pregnant women from Africa
IRAS ID
338435
Contact name
Anna Bote-Casamitjana
Contact email
Sponsor organisation
University College London Hospital, , Joint Research Office, UCLH/UCL Joint Research Office
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Malaria poses a significant global health challenge, particularly for pregnant women who are more susceptible to infection, increasing the risk of complications and disease. The World Health Organization recommends preventive therapy for pregnant women in high-transmission areas. However, data on asymptomatic malaria, especially in non-endemic countries, is lacking.
Despite London's considerable number of births from African-origin mothers, evidence-based recommendations for screening asymptomatic malaria are absent, leading to potential undiagnosed complications and disparities in maternity care. This mixed methods study, including a cross-sectional survey and in-depth interviews, aims to assess the prevalence of asymptomatic malaria.
Pregnant women of sub-Saharan African origin who travelled or migrated from malaria-endemic countries within 24 months will be recruited at the University College London Hospitals and Guy’s and St Thomas' Hospital antenatal care services. A UKAS-accredited PCR will screen for asymptomatic malaria, and positive cases will receive further evaluation and treatment. Interviews aim to understand perceptions, barriers to healthcare, and knowledge about malaria.
This research, the first of its kind in London, addresses the gap in knowledge regarding asymptomatic malaria in at-risk pregnant women. The findings could influence screening guidelines and the way for future studies on the consequences of asymptomatic malaria in migrant populations. Ultimately, the study contributes to a comprehensive approach to malaria prevention and care for pregnant women, emphasising the importance of addressing this complex issue, especially in non-endemic regions.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
24/NW/0180
Date of REC Opinion
30 May 2024
REC opinion
Favourable Opinion