Pain in People with Parkinson’s/PPwP
Research type
Research Study
Full title
Improving assessment and understanding of pain in people with Parkinson’s
IRAS ID
344674
Contact name
K Ray Chaudhuri
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Parkinson’s disease (PD) is the second most prevalent neurodegenerative condition globally, affecting 6.1 million individuals, with cases expected to double in the next 30 years (Dorsey et al., 2018; Tolosa et al., 2021). Among a myriad of symptoms, up to 85% of people with Parkinson’s (PwP) experience chronic pain (Frederic Viseux et al., 2023), nearly double the rate in the general older population (Allen et al., 2024). Chronic pain in PwP is influenced by complex biopsychosocial factors, as well as disease progression (Edinoff et al., 2020; Alfaro-Rodriguez et al., 2022). Given the incomplete understanding of pain mechanisms in PD, clinical management often focuses on symptoms rather than underlying causes. This study will address this gap by creating an individualised holistic pain assessment for PwP.
This observational study aims to understand the associations between biopsychosocial factors and chronic pain in PwP over time. We will use Ecological Momentary Assessment (EMA) and sensory profiling to investigate pain-related factors and identify distinct patient subgroups. EMA provides a detailed, real-time assessment of pain and psychosocial factors in daily life, offering valuable insights into the dynamic nature of pain experiences. Analysing EMA data will yield a longitudinal understanding of how biopsychosocial factors contribute to pain. Combining this approach with psychophysical assessments will help build individual sensory profiles, with the ultimate goal of identifying targets for novel management treatments and supporting early-phase clinical trials. Finally, in-depth interviews will be held to discuss patients' experience of completing the EMA as well as their data. We will explore how it can help them better understand and address the main factors influencing their pain.
Somatosensory testing will be conducted at the Movement Disorders outpatient clinic at the Parkinson’s Foundation Centre of Excellence, King’s College Hospital. EMA will involve three daily smartphone assessments, taking up to fifteen minutes a day for fourteen days. A subset of participants will be invited for a retest of the somatosensory testing and an interview after completion of EMA.
References
Allen, N. E., Romaliiska, O., & Naisby, J. (2024). Pain and the Non-Pharmacological Management of Pain in People with Parkinson’s Disease. Journal of Parkinson’s Disease, Preprint(Preprint), 1–16. https://doi.org/10.3233/JPD-230227
Bonilla-Jaime, H., Sánchez-Salcedo, J. A., Estevez-Cabrera, M. M., Molina-Jiménez, T., Cortes-Altamirano, J. L., & Alfaro-Rodríguez, A. (2022). Depression and Pain: Use of Antidepressants. Current Neuropharmacology, 20(2), 384-402. https://doi.org/10.2174/1570159X19666210609161447
Dorsey, E. R., Elbaz, A., Nichols, E., Abd-Allah, F., Abdelalim, A., Adsuar, J. C., Ansha, M. G., Brayne, C., Choi, J.-Y. J., Collado-Mateo, D., Dahodwala, N., Do, H. P., Edessa, D., Endres, M., Fereshtehnejad, S.-M., Foreman, K. J., Gankpe, F. G., Gupta, R., Hankey, G. J., . . . Murray, C. J. L. (2018). Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17(11), 939–953. https://doi.org/10.1016/s1474-4422(18)30295-3
Edinoff, A., Sathivadivel, N., McBride, T., Parker, A., Okeagu, C., Kaye, A. D., Kaye, A. M., Kaye, J. S., Kaye, R. J., Sheth, M. M., Viswanath, O., & Urits, I. (2020). Chronic Pain Treatment Strategies in Parkinson’s Disease. Neurology International, 12(3), 61-76. https://doi.org/10.3390/neurolint12030014
Frederic Viseux, Delval, A., Simoneau, M., & Luc Defebvre. (2023). Pain and Parkinson’s disease: Current mechanism and management updates. European Journal of Pain, 27(5), 553–567. https://doi.org/10.1002/ejp.2096
Tolosa, E., Garrido, A., Scholz, S. W., & Poewe, W. (2021). Challenges in the diagnosis of Parkinson’s disease. The Lancet Neurology, 20(5), 385–397. https://doi.org/10.1016/S1474-4422(21)00030-2
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
24/NE/0204
Date of REC Opinion
5 Nov 2024
REC opinion
Favourable Opinion