PAGE - Peritoneal diAlysis and Glucose Exposure V1.2
Research type
Research Study
Full title
Glycaemic Variability in Peritoneal Dialysis
IRAS ID
225993
Contact name
Mark Gilchrist
Contact email
Duration of Study in the UK
1 years, 0 months, 4 days
Research summary
For people with kidney failure the work of the kidneys is done by dialysis. Peritoneal dialysis is one form of dialysis that patients can do every day in their own home. A plastic tube placed surgically in the abdominal wall allows dialysis fluid to be drained into the abdominal cavity. Toxins that would normally be removed by the kidneys and excess fluid the body doesn’t need pass through a natural membrane in the abdomen into the dialysis fluid. The dialysis fluid is then drained out and discarded.
People on dialysis are at much higher risk of developing heart disease than the general population. One factor which may contribute to this is the large amount of sugar that is used in the peritoneal dialysis fluid. The sugar is required in the dialysis fluid to stimulate the movement of toxins out of the body. But some of the sugar in the fluid passes from the abdomen into the body. We know that uncontrolled sugar levels in the blood can lead to diabetes, heart attacks and strokes.
We will be asking patients who don’t have diabetes to wear a small glucose sensor on their arm for 72 hours. Half of these patients will be on peritoneal dialysis and the other half will be patients with declining kidney function who are not yet on dialysis This will allow us to measure what effect the process of peritoneal dialysis has on blood sugar levels.
We hope that a greater understanding of this process will help us to develop treatments which may be able to protect against some of these damaging effects. And ultimately improve patients’ quality of life.REC name
South Central - Hampshire A Research Ethics Committee
REC reference
17/SC/0266
Date of REC Opinion
25 May 2017
REC opinion
Favourable Opinion