• Research type

    Research Study

  • Full title

    Paediatric Sjögren syndrome Cohort study and Repository (PaedSSCoRe)



  • Contact name

    Coziana Ciurtin

  • Contact email

  • Sponsor organisation

    Joint Research office, UCL

  • Identifier

    Z6364106/2020/06/149, UCL’s Data Protection Policy

  • Duration of Study in the UK

    9 years, 11 months, 28 days

  • Research summary

    Sjögren syndrome (SS) in adults is characterised by inflammation of the exocrine glands, principally the salivary and lacrimal glands resulting in xerostomia (dry mouth) and xerophthalmia (dry eyes).It can also present with more extensive exocrinopathy as well as extra-glandular, systemic features.

    SS is defined as primary SS (pSS) when it occurs in isolation, and as secondary SS, if associated with other autoimmune conditions. The incidence and prevalence rates of SS vary depending on the population. To date, there have been no studies reporting accurate incidence or prevalence of SS in childhood. Childhood onset SS defined as disease diagnosed before 18 years of age is believed to be rare; however, it is likely it is under-recognised and therefore under-diagnosed.

    The overarching aim of this study is to identify epidemiological, clinical and laboratory characteristics of paediatric SS in a UK multi-centre cohort of patients. Using this data our goal is to develop universally accepted classification criteria that could be validated for use in a paediatric population.

    Inclusion criterion forthe study and repository is a diagnosis of SS made before 18 years by the referring physician. A data collection pack will be sent to authors willing to participate. Information collected will include but not exclusive to: demographic, clinical and laboratory/histological data at diagnosis and subsequent follow-up appointments. Biological samples including blood, tears, saliva, urine and glandular and extra-glandular (e.g. renal) tissue will be collected prospectively if available. Outcome measures related to disease activity and damage, as well as patient reported outcomes will also be collected at set time points (every 6 months) and during flares.

    PaedSSCoRe will capture data on a significant cohort of children with SS providing a powerful resource to help improve our understanding Prospective data collection will allow a fuller analysis of poor prognostic features, impact of therapy and damage accrual, and variable outcome of childhood SS.

  • REC name

    South Central - Oxford A Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    11 Jan 2021

  • REC opinion

    Further Information Favourable Opinion