Paediatric Cell Atlas
Research type
Research Study
Full title
Pediatric Brain Map Consortium that will create an open access cellular resolution molecular and spatial atlas of the developing human motor cortex at stages of infancy, childhood, and early adolescence.
IRAS ID
322358
Contact name
Carolyn Read
Contact email
Sponsor organisation
University of Cambridge, School of Clinical Medicine
Duration of Study in the UK
4 years, 11 months, 10 days
Research summary
This project will contribute to the long-term goal to mapping the developing human brain over time. It will start by looking at the cells present in the brain that are responsible for motor control, how we move our body. We will stain and look at the brain cells from samples acquired in infancy, childhood, and early adolescence, and make a map of these cells and the genes they express across space and time. The scale and scope of the challenge is large requiring a collaborative team from the UK and US. UCSF investigators will provide donated brain tissue through the Pediatric Brain Bank supported by Benoitt Children’s Hospital and Zuckerberg San Francisco General Hospital. This tissue will be shared with colleagues at Cambridge University and Wellcome Sanger Institute, who will help produce the map and make the data accessible across sites and to the wider scientific community. Out vision is to provide an unprecedented view of the developing brain to chart and identify human-specific features relevant to neurodevelopment and disease.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
22/EE/0308
Date of REC Opinion
28 Dec 2022
REC opinion
Favourable Opinion