Pacing in Heart Failure Study
Research type
Research Study
Full title
The Effect of Bi-ventricular Pacing in Heart Failure with preserved Left Ventricular Ejection Fraction: A Pilot Mechanistic Analysis
IRAS ID
203878
Contact name
Zaheer Yousef
Contact email
Sponsor organisation
Cardiff and Vale University Local Health Board
Clinicaltrials.gov Identifier
16/LO/1610, REC Reference
Duration of Study in the UK
1 years, 5 months, 29 days
Research summary
Heart Failure with preserved ejection fraction (HFpEF) accounts for half of all patients with heart failure. For patients with a reduced ejection fraction (i.e. the amount of blood pushed out of the heart with each beat is less than normal [50%]) there are many treatments that have been shown to reduce mortality and hospital admission. These treatments however, have not been shown to work in HFpEF, and so there is a push to discover treatments that can improve mortality and quality of life for these patients. We have previously shown that patients with HFpEF have flattening of the wall between the 2 main pumping chambers of the heart (the ventricular septum) during exercise, and we believe that this is the cause of lower exercise tolerance in these patients. We will investigate the hypothesis that pacing (sending an electrical impulse to heart muscle to make it contract) of the heart will correct the flattening of the septum during exercise, and improve the heart's ability to pump blood during exercise. This study will inform larger studies into pacing in HFpEF patients to improve exercise tolerance.
REC name
London - Dulwich Research Ethics Committee
REC reference
16/LO/1610
Date of REC Opinion
5 Oct 2016
REC opinion
Further Information Favourable Opinion