PACIFIC Stroke - 19766 - Non-cardioembolic ischaemic stroke
Research type
Research Study
Full title
Multicenter, randomized, placebo-controlled, double-blind, parallel group, dose-finding Phase 2 study to evaluate efficacy and safety of BAY 2433334 in patients following an acute noncardioembolic ischaemic stroke
IRAS ID
275993
Contact name
Thomson Robinson
Contact email
Sponsor organisation
Bayer
Eudract number
2019-003431-33
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 1 months, 19 days
Research summary
Summary of Research
The purpose of this study is to try to find the best dose of the new drug BAY 2433334 to give to participants and to look at how well BAY 2433334 works on top of antiplatelet therapy in patients following a recent non-cardioembolic ischaemic stroke which occurs when a blood clot that has not formed in the heart traveled to the brain. BAY 2433334, works by blocking a step of the blood clotting process in our body and thins the blood and is a so called oral FXIa inhibitor.
Summary of Results
Websynopsis (in technical language): see on Bayer Clinical Trials Explorer: https://eur03.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbVPIP5oH8HR7Fy-2FpAc9Ye47jmj-2F-2FrxoOJPp-2BFrK-2F4EOxxTF-2FhlhHTgcEQe4CY6IYsg-3D-3D9Jb7_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL-2BxAI2vkfeUJugZE0IFgmyPdhzWgpLW2KV-2BBxB4CaK-2BdRoT1emiFuMmVuEp3LdzDqkCTiHqgZO14R1kmPJDtYoGyLU8zb3-2Fb-2FYOkGClxUYL4A5-2F2atAb-2B8T7IjKyPFUpYOXSpW1BKEAn0XtrWFiBil3biCx8rdIf-2Fxq5WJ80bZxw-3D-3D&data=05%7C01%7Capprovals%40hra.nhs.uk%7C56458f7aac6f4f75f6ca08db3482b9d5%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638161508288806465%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=KlDcTGLryEZsSrWheY%2FSkx%2Bexnaipwdt70agerkwfsg%3D&reserved=0
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
20/EE/0031
Date of REC Opinion
2 Apr 2020
REC opinion
Further Information Favourable Opinion