PACE-KD
Research type
Research Study
Full title
Participant Acceptability of Exercise in Kidney Disease (PACE-KD)
IRAS ID
216043
Contact name
Alice Smith
Contact email
Sponsor organisation
University Hospitals of Leicester NHS Trust
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Kidney disease patients often suffer from poor quality of life and many health problems such as heart disease, infections, tiredness and muscle weakness. Having a kidney transplant can transform the life of a patient whose kidneys have failed through disease. However, a high rate of heart disease in these patients limits the survival of the kidney and the length and quality of life.
There is a lack of rigorous research into the role of increased physical activity in the management of cardiovascular risk in kidney transplant patients. Regular exercise is likely to have cardiovascular benefits for renal transplant patients, yet strategies to increase physical activity are not currently part of routine care. Indeed recent consensus recommendations from experts and stakeholders highlighted the strong need for a priority research agenda in exercise for solid organ transplant recipients to improve cardiovascular outcomes.
Given their unusual, non-traditional cardiovascular risk factors and precarious balance of immune function, current guidelines on optimal frequency, intensity, time and mode applicable to the general population and other long term conditions may not be appropriate for this population. Appropriate guidance is therefore absolutely fundamental to improve cardiovascular outcomes and graft survival and to promote self-management of cardiovascular disease risk in these vulnerable people.
The study is funded by Heart Research UK and seeks to compare the feasibility of three different aerobic exercise programmes in renal transplant recipients. Patients will be randomly assigned to one of the three groups which include two high intensity interval training programmes and one continuous aerobic exercise programme.
REC name
East Midlands - Nottingham 2 Research Ethics Committee
REC reference
16/EM/0482
Date of REC Opinion
4 Jan 2017
REC opinion
Further Information Favourable Opinion