Oxyperform study
Research type
Research Study
Full title
The effect of oxygen on exercise performance in chronic heart failure
IRAS ID
149052
Contact name
Andrew Clark
Contact email
Sponsor organisation
Research and Development Office
Eudract number
2014-003380-38
Research summary
The use of oxygen in heart failure has become normal practice over the past decade.
Multiple large cohort and randomised controlled trials have identified clear benefits for the use of medications such as beta blockers, ace-inhibitors and diuretics in providing improvements to mortality or symptom control in heart failure. The use of oxygen in patients with chronic heart failure has not been as well evidenced with a lack of systematic research. With a growing interest in the use of oxygen, the Cochrane review (2010) concluded that the administration of oxygen during myocardial infarction has limited evidenced advantages and may in fact be associated with a higher mortality.
The most recent NICE guidance regarding chronic heart failure updated in 2010 do not discuss the role of oxygen therapy which further highlights the need for clarification regarding the disparity between guidelines and clinical practice. It is therefore appropriate that the role of oxygen should also be further evaluated in the context of heart failure.
The proposed cross-over randomised study is a pilot to investigate the effects of short term administration of oxygen has on exercise capacity in patients with chronic heart failure. Following informed consent, patients will complete exercise sessions on a bike ergometer using a standardised protocol whilst receiving 1 concentration of oxygen randomised between (21, 28 & 40%) given through a standard venturi mask. Participants will be asked to return to the department once weekly over a further 2 weeks to undergo exercise sessions with the remaining 2 oxygen concentrations.REC name
West of Scotland REC 1
REC reference
14/WS/1086
Date of REC Opinion
23 Sep 2014
REC opinion
Further Information Favourable Opinion